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KMID : 1123920070210030679
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 3 p.679 ~ p.687
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Effects of Onchung-eum Administration along with Samhwangseze-gamibang on Treatment Atopic Dermatitis Development in NC/Nga Mice
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Hong Chul-Hee
Seo Eun-Sung
Won Young-Ho
Kim Young-Keun
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Abstract
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The purpose of this study is to examine closely effect that Onchung-eum(OC) and Samhwangseze-gamibang(SG) used to atopic dermatitis disease patient get in atopy eruption control experimentally. Atopic dermatitis(AD) of molecular mechanism underlying it’s effectiveness is unknown. We analyzed the expression the clinical severities in 13 and 16 weeks old NC/Nga mice, and the spleen weight of OC with SG treated NC/Nga mice, and mRNA expression levels of IL-4, IL-5, and CCR3 in the skin tissues of OC with SG treated NC/Nga mice, and IL-1, TNF-, IL-6 express of gene, and Histological observation of the ear and skin tissues, and than IgE, IL-4, IL-5, IL-6, IgM, IgGl levels in the serum of OC with SG treated NC/Nga mouse group compared to the untreated control mouse group. Also, We examined cell toxicity that of OC is safety the strength of 10, 50, 100ppm and inflammatory RAW 264.7 in the serum of OC. Thus in these present study diverse immune responses in terms of chemical mediators related to AD were investigated using an atopic mouse model NC/Nga after OC along with 5G. At the result that OC along with SG treat is can effective use for the treatment of atopic dermatitis(AD).
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KEYWORD
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온청음(溫淸飮), 삼황세제가미방(三黃洗劑加味方) , Onchung-eum(OC), Samhwangseje-gamibang(SG), External treatment, Atopic dermatitis, NC/Nga mouse
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